{"id":5929,"date":"2023-02-05T17:25:29","date_gmt":"2023-02-05T17:25:29","guid":{"rendered":"https:\/\/velea.ro\/univapollonia\/?page_id=5929"},"modified":"2023-02-17T05:27:56","modified_gmt":"2023-02-17T05:27:56","slug":"2peptarglu-objectives-and-activities-of-the-project","status":"publish","type":"page","link":"https:\/\/www.univapollonia.ro\/en\/2peptarglu\/2peptarglu-objectives-and-activities-of-the-project\/","title":{"rendered":"2PepTargLu \u2013 objectives and activities of the project"},"content":{"rendered":"<p>[vc_row][vc_column width=&#8221;1\/4&#8243;]<div class=\"widget_sidebar_menu main-sidebar-menu\"><div class=\"sidebar-menu-wrap\"><ul id=\"menu-2peptarglu-en\" class=\"sidebar-menu\"><li id=\"nav-menu-item-6526\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children  has-sub narrow \"><a href=\"https:\/\/www.univapollonia.ro\/en\/2peptarglu\/\">2PepTargLu<\/a><span class=\"arrow\"><\/span>\n<div class=\"popup\"><div class=\"inner\" style=\"\"><ul class=\"sub-menu\">\n\t<li id=\"nav-menu-item-6530\" class=\"menu-item menu-item-type-post_type menu-item-object-page \" data-cols=\"1\"><a href=\"https:\/\/www.univapollonia.ro\/en\/2peptarglu\/2peptarglu-project-summary\/\">2PepTargLu \u2013 project summary<\/a><\/li>\n\t<li id=\"nav-menu-item-6529\" class=\"menu-item menu-item-type-post_type menu-item-object-page \" data-cols=\"1\"><a href=\"https:\/\/www.univapollonia.ro\/en\/2peptarglu\/2peptarglu-objectives-and-activities-of-the-project\/\">2PepTargLu \u2013 objectives and activities of the project<\/a><\/li>\n\t<li id=\"nav-menu-item-6532\" class=\"menu-item menu-item-type-post_type menu-item-object-page \" data-cols=\"1\"><a href=\"https:\/\/www.univapollonia.ro\/en\/2peptarglu\/2peptarglu-results\/\">2PepTargLu \u2013 results<\/a><\/li>\n\t<li id=\"nav-menu-item-6531\" class=\"menu-item menu-item-type-post_type menu-item-object-page \" data-cols=\"1\"><a href=\"https:\/\/www.univapollonia.ro\/en\/2peptarglu\/2peptarglu-project-team\/\">2PepTargLu \u2013 project team<\/a><\/li>\n\t<li id=\"nav-menu-item-6528\" class=\"menu-item menu-item-type-post_type menu-item-object-page \" data-cols=\"1\"><a href=\"https:\/\/www.univapollonia.ro\/en\/2peptarglu\/2peptarglu-dissemination\/\">2PepTargLu \u2013 dissemination<\/a><\/li>\n\t<li id=\"nav-menu-item-6527\" class=\"menu-item menu-item-type-post_type menu-item-object-page \" data-cols=\"1\"><a href=\"https:\/\/www.univapollonia.ro\/en\/2peptarglu\/2peptarglu-contact\/\">2PepTargLu \u2013 contact<\/a><\/li>\n<\/ul><\/div><\/div>\n<\/li>\n<\/ul><\/div><\/div>[\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_column_text]<\/p>\n<div id=\"the-content\">\n<p><strong>1. Project objectives<\/strong><\/p>\n<p>The<em>\u00a0<strong>main objective<\/strong><\/em>\u00a0of this proposal is related to the preparation of peptides-functionalized nano\/microparticles (N\/MPs), based on carboxymethyl chitosan (CMCS) and poly(vinyl alcohol) (PVA), with dual active targeting for the treatment of pulmonary infections. Chitosan (CS), a linear polysaccharide of randomly distributed N-acetyl glucosamine and glucosamine units, exhibits minimal foreign body reaction, controllable mechanical\/biodegradation properties, biocompatibility, hydrophilicity, non-toxicity, nonantigenicity, and anti-microbial activity as well as bio-adherence and cell affinity. In addition, PVA is a non-toxic synthetic copolymer with good elasticity. Moreover, the addition of PVA aims to control the hydrophilicity of the system in order to avoid the use of additional crosslinker (a common option to control the network properties through crosslinking density). The mechanical properties brought by the PVA and the mucoadhesive properties of the CS represent a viable combination for the preparation of porous N\/MPs.<\/p>\n<p><strong>2. Project activities<\/strong><\/p>\n<p>A1: Synthesis and characterization of the precursors for the further preparation of N\/MPs<\/p>\n<p>A2: Design and synthesis of peptides-functionalized nano\/microparticles (2PEP-N\/MPs)<\/p>\n<p>A3: Characterization and optimization of peptides-functionalized nano\/microparticles (2PEP-N\/MPs)<\/p>\n<p>A4: Evaluation of the biomaterial properties of the 2PEP-N\/MPs<\/p>\n<p>A5:<em>\u00a0In vitro\u00a0<\/em>assessment of the\u00a0<em>2PEP-N\/MPs<\/em><\/p>\n<p>A6:\u00a0<em>In vitro<\/em>\u00a0evaluation of apoptosis and anti-inflammatory potential of 2PEP-N \/ MPs and preliminary\u00a0<em>in vivo<\/em>\u00a0tests.<\/p>\n<\/div>\n<p>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column width=&#8221;1\/4&#8243;][\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_column_text] 1. Project objectives The\u00a0main objective\u00a0of this proposal is related to the preparation of peptides-functionalized nano\/microparticles (N\/MPs), based on carboxymethyl chitosan (CMCS) and poly(vinyl alcohol) (PVA), with dual active targeting for the treatment of pulmonary infections. Chitosan (CS), a linear polysaccharide of randomly distributed N-acetyl glucosamine and glucosamine units, exhibits minimal foreign body [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":5920,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"inline_featured_image":false,"footnotes":""},"class_list":["post-5929","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.univapollonia.ro\/en\/wp-json\/wp\/v2\/pages\/5929","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.univapollonia.ro\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.univapollonia.ro\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.univapollonia.ro\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.univapollonia.ro\/en\/wp-json\/wp\/v2\/comments?post=5929"}],"version-history":[{"count":3,"href":"https:\/\/www.univapollonia.ro\/en\/wp-json\/wp\/v2\/pages\/5929\/revisions"}],"predecessor-version":[{"id":6619,"href":"https:\/\/www.univapollonia.ro\/en\/wp-json\/wp\/v2\/pages\/5929\/revisions\/6619"}],"up":[{"embeddable":true,"href":"https:\/\/www.univapollonia.ro\/en\/wp-json\/wp\/v2\/pages\/5920"}],"wp:attachment":[{"href":"https:\/\/www.univapollonia.ro\/en\/wp-json\/wp\/v2\/media?parent=5929"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}