Project objectives

The scope of the project consists in development, optimization and validation of an advanced biocomposite system based on peptides-functionalized microparticles with embedded zinc oxide (ZnO) nanoparticles, for the active targeting and treatment of pulmonary infections. The microparticles will be surface-functionalized on the one hand with the CGSPGWVRC peptide that will be used for active targeting of alveolar capillary endothelial cells, and on the other hand with the indolicidin (IN) peptide used for targeting the bacterial cells responsible for pneumonia. ZnO nanoparticles will be used to replace antibiotics which, due to excessive use or their incorrect use can lead to a decrease in their therapeutic efficacy. We anticipate the preparation of materials with advanced properties, non-toxic, biocompatible and with good chemical stability, which will actively target both alveolar capillary endothelial cells and bacterial cells owing to a strong and persistent antibacterial activity.

Project activities

A1: Preparation and characterization of novel peptide-functionalized microparticles

A2: Optimization of PMPsZO microparticles from a structural, dimensional and biomaterial properties point of view and in vitro evaluation

A3: Antimicrobial and anti-inflammatory activity of optimized PMPsZO microparticles

 

General information

Project summary

Objectives and activities of the project

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Prroject results

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